Sabroe Ian, Parker Lisa C, Dockrell David H, Davies Donna E, Dower Steven K, Whyte Moira K B
Academic Unit of Respiratory Medicine, School of Medicine and Biomedical Sciences, University of Sheffield, L Floor, Royal Hallamshire Hospital, Sheffield, UK.
Am J Respir Crit Care Med. 2007 Feb 15;175(4):306-11. doi: 10.1164/rccm.200606-777PP. Epub 2006 Nov 30.
Recent advances in the field of innate immunity have driven an important reappraisal of the role of these processes in airway disease. Various strands of evidence indicate that resident cells, such as macrophages and epithelial cells, have central importance in the initiation of inflammation. Macrophage activation has the potential to regulate not just typical aspects of innate immunity but also, via a variety of intricate cell-cell networks, adaptive responses and responses characterized by Th2-type cytokine production. In turn, such adaptive immune processes modify the phenotype and function of the innate immune system. Cooperative responses between monocytic cells and tissue cells are likely to be crucial to the generation of effective inflammatory responses, and a realization of the importance of these networks is providing a new way of identifying antiinflammatory therapies. Importantly, the repeated cycles of allergic and nonallergic inflammation that comprise chronic human airway disease are not necessarily well described by current terminology, and we propose and describe a concept of contiguous immunity, in which continual bidirectional cross-talk between innate and adaptive immunity describes disease processes more accurately.
固有免疫领域的最新进展推动了对这些过程在气道疾病中作用的重要重新评估。多方面证据表明，诸如巨噬细胞和上皮细胞等驻留细胞在炎症起始中具有核心重要性。巨噬细胞激活不仅有可能调节固有免疫的典型方面，还能通过各种复杂的细胞间网络调节适应性反应以及以Th2型细胞因子产生为特征的反应。反过来，这种适应性免疫过程会改变固有免疫系统的表型和功能。单核细胞与组织细胞之间的协同反应可能对有效炎症反应的产生至关重要，认识到这些网络的重要性正在为确定抗炎疗法提供新途径。重要的是，构成慢性人类气道疾病的过敏和非过敏炎症的反复循环，当前术语不一定能很好地描述，我们提出并描述了一种连续免疫的概念，即固有免疫和适应性免疫之间持续的双向相互作用能更准确地描述疾病过程。
