Castracane V D, Tankenow L F, Shaikh A A
J Reprod Fertil. 1975 Sep;44(3):473-9. doi: 10.1530/jrf.0.0440473.
Aspirin and indomethacin, inhibitors of prostaglandin biosynthesis, were utilized to determine the role of prostaglandins (PGs) in ovarian weight gain in rats following unilateral ovariectomy or treatment with PMSG. After unilateral ovariectomy, the compensatory ovarian hypertrophy was 185-0% compared with 139-8% and 97-5% in rats treated with indomethacin and aspirin, respectively. The adrenal weights in rats treated with aspirin were also reduced significantly. Administration of PGE2 or PGF2alpha with aspirin reversed the effect of aspirin on the adrenals but had no effect on the ovarian weight. Indomethacin and aspirin treatment of animals injected with PMSG also reduced the ovarian weight gain. If 100 mug PGE2 were given twice daily, this effect was reversed in both groups but thrice daily administration had no effect on rats receiving aspirin. In PMSG-treated rats, 100 mug PGF2alpha twice daily did not reverse the effect of indomethacin and aspirin, and actually enhanced the effect of aspirin.
阿司匹林和消炎痛作为前列腺素生物合成的抑制剂，被用于确定前列腺素（PGs）在大鼠单侧卵巢切除或注射孕马血清促性腺激素（PMSG）后卵巢重量增加中的作用。单侧卵巢切除后，代偿性卵巢肥大率为185.0%，而分别用消炎痛和阿司匹林处理的大鼠，其代偿性卵巢肥大率为139.8%和97.5%。用阿司匹林处理的大鼠肾上腺重量也显著降低。与阿司匹林同时给予PGE2或PGF2α可逆转阿司匹林对肾上腺的作用，但对卵巢重量无影响。用消炎痛和阿司匹林处理注射了PMSG的动物，也会降低卵巢重量增加。如果每天两次给予100微克PGE2，两组的这种作用均可逆转，但每天三次给药对接受阿司匹林处理的大鼠无影响。在注射PMSG的大鼠中，每天两次给予100微克PGF2α不能逆转消炎痛和阿司匹林的作用，实际上还增强了阿司匹林的作用。
