Cornberg Markus, Deterding Katja, Manns Michael P
German Competence Network for Viral Hepatitis (Kompetenznetz Hepatitis), Medizinische Hochschule Hannover, Department of Gastroenterology, Hepatology, and Endocrinology, Carl-Neuberg Str. 1, D-30625 Hannover, Germany.
Expert Rev Anti Infect Ther. 2006 Oct;4(5):781-93. doi: 10.1586/14787210.4.5.781.
The treatment of hepatitis C virus (HCV) infection has developed enormously over recent years. Early treatment of acute HCV infection with interferon-alpha can prevent chronicity and a significant proportion of patients with chronic HCV can be cured with the current standard therapy consisting of pegylated interferon-alpha and ribavirin. However, the improvement of current treatment regimens and the development of new antiviral drugs will be essential within the next few years. This review focuses on the present and future concepts for treating HCV infection, including prevention of infection, antiviral therapy of acute and chronic HCV and the management of patients after liver transplantation.
近年来，丙型肝炎病毒（HCV）感染的治疗取得了巨大进展。用α干扰素早期治疗急性HCV感染可预防慢性化，并且相当一部分慢性HCV患者可通过目前由聚乙二醇化α干扰素和利巴韦林组成的标准疗法治愈。然而，在未来几年内改进当前的治疗方案并开发新的抗病毒药物至关重要。本综述重点关注治疗HCV感染的当前和未来概念，包括感染的预防、急性和慢性HCV的抗病毒治疗以及肝移植后患者的管理。
