Bassetti Matteo, Righi Elda, Tumbarello Mario, Di Biagio Antonio, Rosso Raffaella, Viscoli Claudio
Clinica Malattie Infettive, A.O. U. San Martino, R. Benzi 10 16132, Genoa, Italy.
Expert Rev Anti Infect Ther. 2006 Oct;4(5):875-85. doi: 10.1586/14787210.4.5.875.
This article reviews the epidemiology, predisposing risk factors and outcome of systemic Candida spp. infections in the intensive care unit setting. Incidence of systemic Candida infections in patients requiring intensive care has increased substantially in recent years; while diagnosis of serious Candida infection may be difficult, the clinical conditions which predispose patients to these infections are now better understood and effective antifungal therapies are becoming increasingly available. Severe fungal infections are generally associated with poor outcomes in these patients. Patients at highest risk for Candida infection may be potential candidates for early, presumptive therapy. In this article we review antifungal treatment, including the use of polyenes, azoles and echinocandines, and the role of prophylaxis.
本文综述了重症监护病房环境下系统性念珠菌属感染的流行病学、易感风险因素及预后。近年来，需要重症监护的患者发生系统性念珠菌感染的发生率大幅上升；虽然严重念珠菌感染的诊断可能困难，但现在对使患者易患这些感染的临床情况有了更好的了解，并且越来越有有效的抗真菌治疗方法。在这些患者中，严重真菌感染通常与不良预后相关。念珠菌感染风险最高的患者可能是早期经验性治疗的潜在候选者。在本文中，我们综述了抗真菌治疗，包括多烯类、唑类和棘白菌素类的使用，以及预防的作用。
