Liberman Uri, Puniyani Amit, Feldman Marcus W
School of Mathematical Sciences, Tel Aviv University, Tel Aviv 69978, Israel.
Theor Popul Biol. 2007 Mar;71(2):230-8. doi: 10.1016/j.tpb.2006.10.002. Epub 2006 Oct 25.
The evolution of fitness interactions between genes at two major loci is studied where the alleles at a third locus modify the epistatic interaction between the two major loci. The epistasis is defined by a parameter epsilon and a matrix structure that specifies the nature of the interactions. When epsilon=0 the two major loci have additive fitnesses, and when these are symmetric the interaction matrices studied here produce symmetric viabilities of the Wright [1952. The genetics of quantitative variability. In: Reeve, E.C.R., Waddington, C.H. (Eds.), Quantitative Inheritance. Her Majesty's Stationary Office, London]-Kimura [1956. A model of a genetic system which leads to closer linkage by natural selection. Evolution 10, 278-281] form. Two such interaction matrices are studied, for one of which epistasis as measured by |epsilon| always increases, and for the other it increases when the linkage between the major loci is tight enough and there is initial linkage disequilibrium. Increase of epistasis does not necessarily coincide with increase in equilibrium mean fitness.
研究了两个主要基因座上基因间适合度相互作用的进化情况，其中第三个基因座上的等位基因会改变这两个主要基因座之间的上位性相互作用。上位性由一个参数ε和一个指定相互作用性质的矩阵结构来定义。当ε = 0时，两个主要基因座具有加性适合度，并且当这些适合度对称时，这里研究的相互作用矩阵会产生赖特[1952年。数量变异性的遗传学。载于：里夫，E.C.R.，沃丁顿，C.H.（编），数量遗传。女王陛下文书局，伦敦] - 木村[1956年。一个通过自然选择导致更紧密连锁的遗传系统模型。进化10，278 - 281]形式的对称生存力。研究了两个这样的相互作用矩阵，对于其中一个，用|ε|衡量的上位性总是增加，而对于另一个，当主要基因座之间的连锁足够紧密且存在初始连锁不平衡时上位性增加。上位性的增加不一定与平衡平均适合度的增加一致。
