Cheverud J M, Routman E J
Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Genetics. 1995 Mar;139(3):1455-61. doi: 10.1093/genetics/139.3.1455.
We present a new parameterization of physiological epistasis that allows the measurement of epistasis separate from its effects on the interaction (epistatic) genetic variance component. Epistasis is the deviation of two-locus genotypic values from the sum of the contributing single-locus genotypic values. This parameterization leads to statistical tests for epistasis given estimates of two-locus genotypic values such as can be obtained from quantitative trait locus studies. The contributions of epistasis to the additive, dominance and interaction genetic variances are specified. Epistasis can make substantial contributions to each of these variance components. This parameterization of epistasis allows general consideration of the role of epistasis in evolution by defining its contribution to the additive genetic variance.
我们提出了一种新的生理上位性参数化方法，该方法能够独立于上位性对互作（上位性）遗传方差成分的影响来测量上位性。上位性是两位点基因型值与各单一位点基因型值之和的偏差。这种参数化方法可在得到两位点基因型值估计值（如通过数量性状位点研究获得）的情况下，对上位性进行统计检验。明确了上位性对加性、显性和互作遗传方差的贡献。上位性可对这些方差成分中的每一个都做出显著贡献。通过定义上位性对加性遗传方差的贡献，这种上位性参数化方法能够全面考量上位性在进化中的作用。
