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蛇毒中低分子量血小板聚集抑制剂的分布

Distribution of low molecular weight platelet aggregation inhibitors from snake venoms.

作者信息

Oyama Etsuko, Takahashi Hidenobu

机构信息

Department of Hygenic Chemistry, Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo 204-8588, Japan.

出版信息

Toxicon. 2007 Mar 1;49(3):293-8. doi: 10.1016/j.toxicon.2006.09.027. Epub 2006 Oct 10.

Abstract

An assay of platelet aggregation inhibitors measured by the turbidimeter using Aggregometer PAM 8C (Mebanix) was performed after each crude snake venom (57 species) was subjected to ultrafiltration using MILLIPORE UFP 1 LGC. The snake venoms of Viperidae (three species), Elapidae (11 species), and Hydrophiidae (two species) inhibited ADP-induced rabbit platelet aggregation. In particular, six venoms of Bitis gabonica, Pseudocerastes persicus, Dendroaspis angusticeps, D. polylepis, Ophiophagus hannah, and N. nigricollis crawshawii strongly inhibited platelet aggregation. Furthermore, adenosine was identified from Bitis gabonica venom using HPLC and FAB/MS analysis.

摘要

在使用MILLIPORE UFP 1 LGC对每种粗制蛇毒(57种)进行超滤后,使用Aggregometer PAM 8C(Mebanix)通过比浊计对血小板聚集抑制剂进行了测定。蝰蛇科(3种)、眼镜蛇科(11种)和海蛇科(2种)的蛇毒抑制了ADP诱导的兔血小板聚集。特别是,加蓬咝蝰、波斯角蝰、黑曼巴、东部绿曼巴、眼镜王蛇和黑颈澳海蛇的六种毒液强烈抑制血小板聚集。此外,使用HPLC和FAB/MS分析从加蓬咝蝰毒液中鉴定出了腺苷。

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