形成脓肿的肉芽肿性淋巴结炎中的单核细胞样B淋巴细胞和上皮样细胞簇。特别提及猫抓病。

Monocytoid B lymphocytes and epithelioid cell clusters in abscess-forming granulomatous lymphadenitis. With special reference to cat scratch disease.

作者信息

Kojima M, Hosomura Y, Itoh H, Johshita T, Ohno Y, Yoshida K, Asano S, Wakasa H, Nakamura S, Suchi T

机构信息

Department of Pathology, Ashikaga Red Cross Hospital, Japan.

出版信息

Acta Pathol Jpn. 1991 May;41(5):363-8. doi: 10.1111/j.1440-1827.1991.tb01659.x.

DOI:10.1111/j.1440-1827.1991.tb01659.x

PMID:1714225

Abstract

In order to clarify the appearance of monocytoid B lymphocytes (MBLs) in abscess-forming granulomatous lymphadenitis (AGL) and the relation between AGL and cat-scratch disease (CSD), 48 cases of AGL were studied histologically. MBLs were present in about 50% of AGL cases. Warthin-Starry (WS) silver stain-positive bacteria, which are the causative agent of CSD, were present in 52.4% of AGL cases with MBLs and 59.2% of AGL cases without MBLs. The appearance of MBLs in AGL was not related to various clinical features, including disease interval from initial lymphadenopathy to lymph node biopsy. Histologically, epithelioid cell clusters appeared in about 70% of MBL-positive AGL cases, but were not observed in MBL-negative AGL. Therefore, a close interaction between MBLs and epithelioid cells in AGL is suggested, and we emphasize that the histological features of some AGL cases resemble those of toxoplasmic lymphadenitis.

摘要

为了阐明单核细胞样B淋巴细胞（MBL）在形成脓肿的肉芽肿性淋巴结炎（AGL）中的表现以及AGL与猫抓病（CSD）之间的关系，对48例AGL进行了组织学研究。约50%的AGL病例中存在MBL。作为CSD病原体的Warthin-Starry（WS）银染色阳性细菌在有MBL的AGL病例中占52.4%，在无MBL的AGL病例中占59.2%。AGL中MBL的出现与各种临床特征无关，包括从最初淋巴结病到淋巴结活检的疾病间隔。组织学上，约70%的MBL阳性AGL病例出现上皮样细胞簇，但在MBL阴性的AGL中未观察到。因此，提示AGL中MBL与上皮样细胞之间存在密切相互作用，并且我们强调一些AGL病例的组织学特征类似于弓形虫淋巴结炎。