Pell Jill P, Walker Andrew, Cobbe Stuart M
University of Glasgow, Scotland, UK.
Curr Opin Cardiol. 2007 Jan;22(1):5-10. doi: 10.1097/HCO.0b013e3280118fec.
To discuss the clinical effectiveness, public health impact and cost-effectiveness of public access defibrillation.
High rates of survival from prehospital ventricular fibrillation have been documented in patients treated by first responders using automated external defibrillators. The recent Public Access Defibrillation trial demonstrated a doubling of cardiac arrest survival in community units where volunteers trained in cardiopulmonary resuscitation were additionally equipped with automated external defibrillators. The cost-effectiveness analysis of the Public Access Defibrillation trial has not yet been published, and previous analyses have lacked full data on cost, outcome, or both. Data from many sources indicate that automated external defibrillator placement at sites with an expected rate of one cardiac arrest per defibrillator per 5 years, as recommended by the American Heart Association, addresses only around 1-2% of prehospital arrests, and will have a minimal impact on population survival.
While highly targeted provision of automated external defibrillators in areas of greatest risk, such as casinos and airports, may be cost-effective, it will have little impact at a population level. Provision of more widespread public access defibrillation to sites with lower incidence of cardiac arrest is unlikely to be cost-effective, and may represent poorer value for money than alternative healthcare interventions in coronary artery disease.
探讨公众可获取除颤的临床有效性、对公共卫生的影响及成本效益。
有文献记载,急救人员使用自动体外除颤器对患者进行治疗后,院外心室颤动患者的存活率很高。最近的公众可获取除颤试验表明,在社区单位中,接受过心肺复苏培训的志愿者额外配备自动体外除颤器后,心脏骤停存活率提高了一倍。公众可获取除颤试验的成本效益分析尚未发表,之前的分析缺乏关于成本、结果或两者的完整数据。许多来源的数据表明,按照美国心脏协会的建议,在预计每5年每台除颤器发生1次心脏骤停的地点放置自动体外除颤器,仅能解决约1%-2%的院外心脏骤停问题,对总体存活率的影响极小。
虽然在赌场和机场等高风险区域有针对性地提供自动体外除颤器可能具有成本效益,但在总体层面影响不大。在心脏骤停发生率较低的地点更广泛地提供公众可获取除颤不太可能具有成本效益,与冠状动脉疾病的其他医疗干预措施相比,可能性价比更低。