Mehrazin M
Department of Neurological Surgery, Dr Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Childs Nerv Syst. 2007 Apr;23(4):391-8. doi: 10.1007/s00381-006-0259-4. Epub 2006 Dec 2.
The aim of this study is to review the results of surgery for pituitary adenomas in children less than 18 years old.
A retrospective review was done of pituitary adenoma patients with the age of less than 18 years who were treated in the period 1979-2003 at Dr. Shariati Hospital.
Twenty-one patients (12 girls and 9 boys) were identified. The age range (mean) in girls and boys was 9-18 (15.8) and 9-17 (14.8) years, respectively. The duration of follow-up was 1-23 (13.4) years. Eight patients (38.1%) had adrenocorticotropic hormone-secreting tumors, 33.3% had prolactin-secreting tumors, 19% had growth hormone-secreting tumors, and 9.53% had nonfunctioning adenomas. Multidisciplinary management included surgery and, if necessary, reoperation with/without radiotherapy and pharmacotherapy. Eleven patients, mostly with prolactinomas, acromegaly, and nonfunctioning adenomas, needed reoperation and radiotherapy. There were two deaths, one of which was because of apoplexy. The biological behavior of pediatric pituitary adenomas seems more aggressive than adults' adenomas. The chance of pituitary apoplexy in pediatric invasive pituitary adenoma is high.
本研究旨在回顾18岁以下儿童垂体腺瘤的手术治疗结果。
对1979年至2003年期间在沙里亚蒂医院接受治疗的年龄小于18岁的垂体腺瘤患者进行回顾性研究。
共确定了21例患者（12名女孩和9名男孩）。女孩和男孩的年龄范围（平均值）分别为9至18岁（15.8岁）和9至17岁（14.8岁）。随访时间为1至23年（13.4年）。8例患者（38.1%）患有促肾上腺皮质激素分泌型肿瘤，33.3%患有催乳素分泌型肿瘤，19%患有生长激素分泌型肿瘤，9.53%患有无功能腺瘤。多学科管理包括手术，必要时进行再次手术，可联合或不联合放疗及药物治疗。11例患者，主要是患有催乳素瘤、肢端肥大症和无功能腺瘤的患者，需要再次手术和放疗。有2例死亡，其中1例死于卒中。儿童垂体腺瘤的生物学行为似乎比成人腺瘤更具侵袭性。儿童侵袭性垂体腺瘤发生垂体卒中的几率较高。
