全血干扰素-γ释放试验检测活动性肺结核的灵敏度较低。
Low sensitivity of a whole-blood interferon-gamma release assay for detection of active tuberculosis.
作者信息
Dewan Puneet K, Grinsdale Jennifer, Kawamura L Masae
机构信息
International Research and Programs Branch, Division of Tuberculosis Elimination, National Center for HIV, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.
出版信息
Clin Infect Dis. 2007 Jan 1;44(1):69-73. doi: 10.1086/509928. Epub 2006 Nov 28.
The sensitivity of an interferon-gamma assay (Quantiferon-TB Gold; Cellestis) was evaluated for the detection of tuberculosis among 242 persons with suspected tuberculosis in San Francisco, California. Thirty-seven subjects had culture-confirmed tuberculosis. Excluding 1 indeterminate result, 23 (64%; 95% confidence interval, 48%-78%) of 36 subjects had positive results using the QuantiFERON-TB Gold assay. The 64% sensitivity suggests that the QuantiFERON-TB Gold assay should not be used alone to exclude active tuberculosis.
在加利福尼亚州旧金山，对242名疑似结核病患者进行了γ干扰素检测（结核菌素金标定量检测；Cellestis公司），以评估其在结核病检测中的敏感性。37名受试者经培养确诊为结核病。排除1例不确定结果后，36名受试者中有23例（64%；95%置信区间为48%-78%）使用结核菌素金标定量检测呈阳性。64%的敏感性表明，结核菌素金标定量检测不应单独用于排除活动性结核病。
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