Delvenne Philippe, Herman Ludivine, Kholod Natalia, Caberg Jean-Hubert, Herfs Michaël, Boniver Jacques, Jacobs Nathalie, Hubert Pascale
Department of Pathology, CRCE-CBIG, B35, University of Liege, CHU Sart Tilman, 4000 Liege, Belgium.
Mol Cell Endocrinol. 2007 Jan 29;264(1-2):1-5. doi: 10.1016/j.mce.2006.10.014. Epub 2006 Dec 4.
If human papillomavirus (HPV) is necessary for the development of (pre)neoplastic lesions of the uterine cervix, it is not sufficient. Among the cofactors involved in the malignant transformation of cells infected by HPV, sex hormones may facilitate the cervical carcinogenesis by different mechanisms, including the induction of squamous metaplasia in the transformation zone of the cervix, interactions between steroid hormones and HPV gene expression and alterations of the local immune microenvironment.
如果人乳头瘤病毒（HPV）是子宫颈（癌前）病变发展所必需的，那么它并不充分。在参与HPV感染细胞恶性转化的辅助因素中，性激素可能通过不同机制促进子宫颈癌发生，包括在子宫颈转化区诱导鳞状化生、类固醇激素与HPV基因表达之间的相互作用以及局部免疫微环境的改变。
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