Park Meyeon, Davidson Rebecca, Fox Kevin
University of Pennsylvania, Philadelphia, PA, USA.
Semin Oncol. 2006 Dec;33(6):664-71. doi: 10.1053/j.seminoncol.2006.08.015.
The occurrence of early-stage breast cancer in premenopausal women who desire children is a considerable clinical challenge. The frequent use of adjuvant cytotoxic chemotherapy can induce ovarian failure and infertility, while the frequent use of adjuvant hormonal therapy is a contraindication to conception. A variety of techniques to preserve fertility in spite of adjuvant chemotherapy are under investigation, with promising early results. Ovarian stimulation with retrieval of eggs for in vitro fertilization and cryopreservation prior to the commencement of chemotherapy seems to hold the greatest promise for patients. There is no evidence that patients treated with curative intent for early-stage breast cancer who subsequently become pregnant have a compromised survival, but patients should be counseled regarding their risk of recurrence in general and whether a high recurrence risk might make subsequent pregnancy and motherhood an unwise choice. The offspring of breast cancer survivors do not appear to suffer deleterious consequences as a result of the diagnosis or treatment of the mother.
对于有生育意愿的绝经前女性而言，早期乳腺癌的发生是一项重大的临床挑战。频繁使用辅助细胞毒性化疗可导致卵巢功能衰竭和不孕，而频繁使用辅助激素治疗则是受孕的禁忌证。尽管正在研究多种在辅助化疗情况下保留生育能力的技术，且早期结果很有前景。在化疗开始前进行卵巢刺激以获取卵子用于体外受精和冷冻保存，这似乎对患者最有希望。没有证据表明接受早期乳腺癌根治性治疗后怀孕的患者生存会受到影响，但一般应向患者咨询其复发风险，以及高复发风险是否会使后续怀孕和为人母成为不明智的选择。乳腺癌幸存者的后代似乎并未因母亲的诊断或治疗而遭受有害后果。
