Frank Eric
Department of Physiology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, Massachusetts 02111, USA.
Neuron. 2006 Dec 7;52(5):745-6. doi: 10.1016/j.neuron.2006.11.013.
A critical step in the formation of correct patterns of sensory inputs to the spinal cord is the guidance of specific subsets of sensory axons to their appropriate target regions. Yoshida et al. demonstrate in this issue of Neuron that a repulsive interaction between plexinA1 and sema6C/6D prevents the growth of proprioceptive sensory axons into the superficial laminae of the dorsal horn where cutaneous sensory axons terminate.
感觉输入脊髓形成正确模式的关键一步是将特定的感觉轴突亚群引导至其合适的靶区域。吉田等人在本期《神经元》杂志中证明，丛蛋白A1与信号素6C/6D之间的排斥性相互作用可阻止本体感觉轴突向背角浅层层生长，而皮肤感觉轴突在此处终止。
