[异丙肾上腺素对犬肺和肠肥大细胞组胺释放的抑制作用]
[Inhibition of histamine liberation in mast cells from the lung and the intestine of the dog by isoproterenol].
作者信息
Vieytes M R, de la Cruz L F, Botana L M
机构信息
Departamento de Fisiología, Facultad de Veterinaria, Lugo, España.
出版信息
Rev Esp Fisiol. 1991 Mar;47(1):19-24.
Enzymatically isolated dog lung and gut mast cells were stimulated with compound 48/80, ionophore A23187, concanavalin A and FNa-Ca. Cell response elicited by A23187, concanavalin A or 48/80 is almost completely inhibited by isoproterenol. Concanavalin A induced histamine release on gut mast cells is high, indicating an elevated degree of sensitization of these cells. Results point to the existence of beta adrenergic inhibitory activity on dog lung and gut mast cells.
用化合物48/80、离子载体A23187、伴刀豆球蛋白A和氟化钠-钙刺激酶法分离的犬肺和肠肥大细胞。异丙肾上腺素几乎完全抑制了由A23187、伴刀豆球蛋白A或48/80引起的细胞反应。伴刀豆球蛋白A诱导肠肥大细胞释放组胺的量很高，表明这些细胞的致敏程度升高。结果表明犬肺和肠肥大细胞存在β-肾上腺素能抑制活性。
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