Papapetrou P D, Jackson I
JAMA. 1975 Nov 24;234(8):847-9.
In two patients who were severely pigmented (Nelson syndrome) following bilateral adrenalectomy for Cushing syndrome, symptoms of hyper-cortisolism developed while they were receiving only physiologic steroid replacement. Cortical assays proved that endogenous cortisol production had not been obliterated. Even after total adrenalectomy, steroid measurement should be performed to guard against adrenocortical excess.
在两名因库欣综合征接受双侧肾上腺切除术后出现严重色素沉着（尼尔森综合征）的患者中，他们仅接受生理剂量的类固醇替代治疗时出现了皮质醇增多症的症状。皮质醇测定证明内源性皮质醇的产生并未被消除。即使在全肾上腺切除术后，也应进行类固醇测量以预防肾上腺皮质功能亢进。
