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假性甲状旁腺功能减退症中循环肾腺苷酸(yamp)排泄的研究(作者译)

[Investigation of cyclic renal adenosinmonophosphate (yamp)-excretion in pseudohypoparathyreoidism (author's transl)].

作者信息

Zabransky S

出版信息

Klin Padiatr. 1975 May;187(3):271-3.

PMID:171472
Abstract

Report on a boy aged 6-1/2 years with pseudohypoparathyroidism. This is due to a genetic lack of PTH inducible adenocyclase. Even during vitamin D treatment renal camp formation by giving PTH extract cannot be stimulated, while in this situation. PTH shows a clearly phosphaturic effect. Whether this is due to a PTH potentiated vitamin D effect is discussed. The assay of camp in urine before and after stimulation with PTH extract has proved the most certain diagnostic criterion.

摘要

关于一名6岁半假性甲状旁腺功能减退男孩的报告。这是由于遗传性缺乏甲状旁腺激素诱导的腺苷酸环化酶所致。即使在维生素D治疗期间,给予甲状旁腺素提取物也无法刺激肾脏中环磷酸腺苷(cAMP)的生成,而在这种情况下,甲状旁腺素显示出明显的促尿磷排泄作用。讨论了这是否归因于甲状旁腺素增强的维生素D作用。用甲状旁腺素提取物刺激前后尿液中环磷酸腺苷的测定已被证明是最可靠的诊断标准。

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