老龄大鼠肝脏中c-jun和c-fos转录本水平升高。
Elevated levels of c-jun and c-fos transcripts in the aged rat liver.
作者信息
Fujita T, Maruyama N
机构信息
Department of Molecular Biology, Tokyo Metropolitan Institute of Gerontology, Japan.
出版信息
Biochem Biophys Res Commun. 1991 Aug 15;178(3):1485-91. doi: 10.1016/0006-291x(91)91061-g.
Age-associated increases of transcript levels of several genes were studied using aged rat liver. Northern hybridization showed marked increases of c-jun, c-fos, and glutathione S-transferase P (GST-P) in 24-month-old rats. These genes have the 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-responsive element called TRE in their structures. Thus, TRE seems to be involved in important age-associated changes of gene expression.
利用老年大鼠肝脏研究了几种基因转录水平与年龄相关的增加情况。Northern杂交显示，24月龄大鼠的c-jun、c-fos和谷胱甘肽S-转移酶P（GST-P）显著增加。这些基因在其结构中具有称为TRE的12-O-十四烷酰佛波醇-13-乙酸酯（TPA）反应元件。因此，TRE似乎参与了与年龄相关的重要基因表达变化。
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