Faulkner Regina L, Low Lawrence K, Cheng Hwai-Jong
Center for Neuroscience, University of California, Davis, CA 95616, USA.
Dev Neurosci. 2007;29(1-2):6-13. doi: 10.1159/000096207.
During early development of the central nervous system (CNS), there is an exuberant outgrowth of projections which later need to be refined to achieve precise connectivity. One widely used strategy for this refinement is axon pruning. Axon pruning has also been suggested to be involved in creating more diverse connection patterns between different species. An understanding of the mechanism of pruning, however, has been elusive in the CNS. Recent studies have focused on a stereotyped pruning event that occurs within the mossy fibers of the developing vertebrate hippocampus. In the following discussion, we will review the cellular and molecular factors that are known to regulate pruning in the hippocampus and highlight some advantages this system presents for future studies on pruning in the developing CNS.
在中枢神经系统（CNS）的早期发育过程中，会有大量的投射生长，这些投射随后需要进行精细化以实现精确的连接。这种精细化广泛采用的一种策略是轴突修剪。轴突修剪也被认为参与了在不同物种之间创建更多样化的连接模式。然而，在中枢神经系统中，对修剪机制的理解一直难以捉摸。最近的研究集中在发育中的脊椎动物海马体苔藓纤维内发生的一种定型修剪事件。在接下来的讨论中，我们将回顾已知调节海马体修剪的细胞和分子因素，并强调该系统为未来发育中枢神经系统修剪研究带来的一些优势。
