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纤维肌痛综合征女性患者的睡眠呼吸障碍

Sleep-disordered breathing among women with fibromyalgia syndrome.

作者信息

Shah Mansi A, Feinberg Stanford, Krishnan Eswar

机构信息

The Reading Hospital and Medical Center, West Reading, Pennsylvania, USA.

出版信息

J Clin Rheumatol. 2006 Dec;12(6):277-81. doi: 10.1097/01.rhu.0000249771.97221.36.

Abstract

BACKGROUND

In clinical practice, polysomnograms ("sleep studies") are seldom ordered for patients with fibromyalgia, although sleep issues dominate the symptom complex. One reason for this is the lack of understanding how information from these studies could aid clinical decisions.

METHODS

The authors conducted a chart review of one rheumatologist's community-based practice where polysomnograms were offered routinely to all women who met the American College of Rheumatology criteria for fibromyalgia. Interpretation of these standardized protocol-based polysomnograms was performed by a board-certified neurologist using standard criteria.

RESULTS

Mean age of the study subjects (n = 23) was 45 (standard deviation, 7.8) years. Median body mass index was 27 kg/m2 (interquartile range 20-48). These women had poor sleep with many arousals (median arousal index 23), apnea-hypopneas (median apnea-hypopnea index 22, interquartile range 17-30). Desaturation was common with half the patients having nadir oxygen saturation less than 87%. Restless legs were detected in polysomnograms among many women who clinically denied it (mean leg movement index 5.8).

CONCLUSIONS

A large proportion of women with fibromyalgia in a general rheumatology practice had sleep-disordered breathing, which can be detected using sleep polysomnograms. Studies are needed to examine if treatment of the commonly detected sleep apnea will have a beneficial effect on symptoms of fibromyalgia.

摘要

背景

在临床实践中,尽管睡眠问题在纤维肌痛患者的症状群中占主导地位,但很少为纤维肌痛患者安排多导睡眠图检查(“睡眠研究”)。原因之一是缺乏对这些研究信息如何有助于临床决策的理解。

方法

作者对一位风湿病学家的社区实践进行了图表回顾,该实践中常规为所有符合美国风湿病学会纤维肌痛标准的女性提供多导睡眠图检查。这些基于标准化方案的多导睡眠图由一名获得董事会认证的神经科医生使用标准标准进行解读。

结果

研究对象(n = 23)的平均年龄为45岁(标准差7.8)。体重指数中位数为27 kg/m²(四分位间距20 - 48)。这些女性睡眠质量差,觉醒频繁(觉醒指数中位数为23),呼吸暂停低通气(呼吸暂停低通气指数中位数为22,四分位间距17 - 30)。低氧血症很常见,一半的患者最低氧饱和度低于87%。在许多临床上否认有不安腿的女性的多导睡眠图中检测到了不安腿(平均腿部运动指数为5.8)。

结论

在普通风湿病实践中,很大一部分纤维肌痛女性存在睡眠呼吸障碍,可通过睡眠多导睡眠图检测到。需要进行研究以检查对常见的睡眠呼吸暂停进行治疗是否会对纤维肌痛症状产生有益影响。

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