Westgate G E, Craggs R I, Gibson W T
Personal Products Research Division, Unilever Research, Sharnbrook, Bedford, U.K.
J Invest Dermatol. 1991 Sep;97(3):417-20. doi: 10.1111/1523-1747.ep12481002.
Immunostaining techniques were used to investigate the relationship between immune cells, proteoglycan, and class I MHC distribution in skin during the hair cycle in rats. The growth stage, anagen, was characterized by absence of class I MHC staining on most cells of the lower follicle and presence of chondroitin proteoglycan in the follicle sheath and dermal papilla. Immune cells were few in number and not associated with follicles. Dramatic changes were observed during regression in catagen; class I MHC was expressed on all follicle epithelium, large numbers of activated macrophages aggregated around the follicles, and the chondroitin proteoglycans disappeared from the follicle sheath and dermal papilla. During the resting stage, telogen, class I MHC remained on cells of the secondary germ, but macrophages and chondroitin proteoglycans were absent. These observations lead us to propose a hypothesis of immune privilege in hair growth.
采用免疫染色技术研究大鼠毛发生长周期中皮肤内免疫细胞、蛋白聚糖和I类主要组织相容性复合体（MHC）分布之间的关系。生长期即毛发生长期，其特征为毛囊下部大多数细胞无I类MHC染色，毛囊鞘和真皮乳头中有硫酸软骨素蛋白聚糖。免疫细胞数量很少，且与毛囊不相关。在退行期即毛发生长中期观察到显著变化；I类MHC在所有毛囊上皮表达，大量活化巨噬细胞聚集在毛囊周围，硫酸软骨素蛋白聚糖从毛囊鞘和真皮乳头消失。在休止期即毛发生长期终期，I类MHC仍存在于次级毛囊胚芽细胞上，但巨噬细胞和硫酸软骨素蛋白聚糖缺失。这些观察结果使我们提出了毛发生长过程中免疫赦免的假说。
