Graça Carlos, Freitas Cristina Setim, Baggio Cristiane Hatsuko, Dalsenter Paulo Roberto, Marques Maria Consuelo Andrade
Department of Pharmacology, Sector of Biological Sciences, Universidade Federal do Paraná, Centro Politécnico, Jardim das Américas, Curitiba, PR, Brazil.
J Ethnopharmacol. 2007 Apr 20;111(1):29-32. doi: 10.1016/j.jep.2006.10.039. Epub 2006 Nov 12.
Mikania laevigata (Asteraceae) is a native plant from South America and popularly used as antispasmodic and to treat respiratory diseases. Coumarin is the major chemical substance found in this plant, which have been shown to have antifertility activity in female rats. This study evaluates the toxicity of the exposure to the Mikania laevigata syrup using coumarin as chemical marker on reproductive endpoints in male Wistar rats. Endpoints including reproductive organs weight, sperm and spermatids numbers and sperm morphology were evaluated. Animals were treated daily with Mikania laevigata syrup (3.5; 7.0 and 14.0mg/kg of coumarin) during 90 days by oral gavage. No alterations were observed in body and organ weights, sperm and spermatids numbers as well as sperm morphology of the male rats after the exposure to the Mikania laevigata syrup. Results therefore suggest absence of male reproductive toxicity of the Mikania laevigata syrup at tested doses.
光叶假泽兰（菊科）是一种原产于南美洲的植物，通常用作解痉剂和治疗呼吸道疾病。香豆素是该植物中发现的主要化学物质，已证明其对雌性大鼠具有抗生育活性。本研究以香豆素为化学标志物，评估光叶假泽兰糖浆暴露对雄性Wistar大鼠生殖终点的毒性。评估了包括生殖器官重量、精子和精子细胞数量以及精子形态等终点指标。通过口服灌胃，在90天内每天给动物喂食光叶假泽兰糖浆（香豆素含量为3.5；7.0和14.0mg/kg）。暴露于光叶假泽兰糖浆后，雄性大鼠的体重、器官重量、精子和精子细胞数量以及精子形态均未观察到变化。因此，结果表明在所测试剂量下，光叶假泽兰糖浆对雄性大鼠无生殖毒性。
