一种以嘧啶并[4,5-d]嘧啶-2,4,5,7-(1H,3H,6H,8H)-四酮为碱基的核糖核苷，它能与天然核苷普遍结合。
A ribonucleoside with pyrimido[4,5-d]pyrimidine-2,4,5,7-(1H,3H,6H,8H)-tetraone as a nucleobase, which universally binds to natural nucleosides.
作者信息
Kuroda Kenji, Kodama Hidehiko, Kataoka Masanori, Hayakawa Yoshihiro
机构信息
Graduate School of Information Science, Nagoya University, Chikusa, Nagoya 464-8601, Japan.
出版信息
Nucleic Acids Symp Ser (Oxf). 2006(50):17-8. doi: 10.1093/nass/nrl009.
PMID:17150795
Abstract
A ribonucleoside with pyrimido[4,5-d]pyrimidine-2,4,5,7-(1H,3H,6H,8H)-tetraone, which is expected to serve as a universal base, was synthesized and binding affinity of this artificial nucleoside to natural nucleosides was investigated by UV analysis. As the result, it was revealed that the artificial derivative universally forms a base pair with four kinds of natural deoxyribonucleosides.
摘要
一种含有嘧啶并[4,5-d]嘧啶-2,4,5,7-(1H,3H,6H,8H)-四酮的核糖核苷被合成出来，该核糖核苷有望作为一种通用碱基，并且通过紫外分析研究了这种人工核苷与天然核苷的结合亲和力。结果表明，这种人工衍生物能与四种天然脱氧核糖核苷普遍形成碱基对。
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