Novel drug releasing system triggered by hybridization with target sequence.

作者信息

Nakayama Shizuka, Nagatsugi Fumi, Sasaki Shigeki

机构信息

Institute of Multidisciplinary Research for Advanced Materials Tohoku University, Katahira 2-1-1, Aoba-ku, Sendai-Shi, Miyagi, Japan.

出版信息

Nucleic Acids Symp Ser (Oxf). 2006(50):143-4. doi: 10.1093/nass/nrl071.

DOI:10.1093/nass/nrl071

PMID:17150858

Abstract

We have already established the strategy of synchronous activation by hybridization, in which the highly reactive cross-linking agent, 2-amino-6-vinylpurine nucleoside analog can be generated from its stable precursors, the phenylsulfide derivatives, by a hybridization-promoted activation process with selectivity to cytosine. In this study, this in situ activation system was applied to method for the drug releasing system triggered by hybridization with the target sequence.

摘要