通过咔唑核苷对DNA中的胸腺嘧啶二聚体进行光诱导修复。
Photoinduced repair of a thymine dimer in DNA via carbazole nucleoside.
作者信息
Yoshimura Yoshinaga, Fujimoto Kenzo
机构信息
School of Materials Science, Japan Advanced Institute of Science and Technology, 1-1 Asahidai, Nomi, Ishikawa 923-1292, Japan.
出版信息
Nucleic Acids Symp Ser (Oxf). 2006(50):151-2. doi: 10.1093/nass/nrl075.
PMID:17150862
Abstract
We report the photoinduced repair of a thymine dimer incorporated in a DNA duplex via oligodeoxynucleotide (ODN) containing carbazole nucleoside (K). The occurrence of an electron transfer between K and thymine dimer is evidenced by fluorescence quenching measurements. K acts as a good electron donor for the photoinduced repair of a thymine dimer.
摘要
我们报道了通过含咔唑核苷（K）的寡脱氧核苷酸（ODN）对掺入DNA双链体中的胸腺嘧啶二聚体进行光诱导修复。荧光猝灭测量证明了K与胸腺嘧啶二聚体之间发生了电子转移。K作为胸腺嘧啶二聚体光诱导修复的良好电子供体。
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