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[动脉导管憩室。创伤性主动脉破裂的原因?]

[Diverticulum of the ductus arteriosus. Cause of traumatic aortic ruptures?].

作者信息

Vogler T, Schulz F, Heyer C, Müller K-M, Müller A M

机构信息

Abteilung für Kinderpathologie, Johannes Gutenberg Universität Mainz, Langenbeckstrasse 1, 55101 Mainz.

出版信息

Chirurg. 2007 Jan;78(1):47-51. doi: 10.1007/s00104-006-1264-6.

Abstract

INTRODUCTION

According to angiographic studies 9-26% of all adult aortae show a ductus arteriosus diverticulum (DAD), i.e. an indention of the aortic wall at the insertion of the obliterated ductus arteriosus. This region is predisposed for traumatic aortic rupture. Up to now fixation at the transition from aorta transversa to fixed aorta descendens is regarded as cause. It is unclear whether ductus diverticulum favours traumatic aortic rupture.

MATERIAL AND METHODS

A total of 143 thoracic aortas (female symbol:37; male symbol:106, 17-91 years) were scanned histomorphologically for DAD. Calcification was quantified by CT multislice volume scan.

RESULTS

A DAD was detected in 44% of macroscopically non-calcified and slightly calcified aortic specimens. Histologically, autochthonal elastic and collagenous fibres of the media were disrupted. CT in macroscopically non-calcified aortas proved isolated calcification in 78%.

DISCUSSION

The incidence of 44% DAD-higher than in angiographic studies-can be explained by the method (histopathology), allowing diagnosis of diverticula down to microm. These morphological alterations are to be seen, at least in part, as a causative factor for the predilection to traumatic aortic ruptures.

摘要

引言

血管造影研究表明,所有成年主动脉中9% - 26%存在动脉导管憩室(DAD),即主动脉壁在闭锁动脉导管插入处的凹陷。该区域易发生创伤性主动脉破裂。目前认为主动脉横部向固定的降主动脉过渡处的固定是其原因。尚不清楚导管憩室是否会增加创伤性主动脉破裂的风险。

材料与方法

对143例胸主动脉(女性37例;男性106例,年龄17 - 91岁)进行组织形态学扫描以检测DAD。通过CT多层容积扫描对钙化进行定量分析。

结果

在44%的宏观上无钙化和轻度钙化的主动脉标本中检测到DAD。组织学上,中膜的固有弹性纤维和胶原纤维遭到破坏。在宏观上无钙化的主动脉中,CT显示78%存在孤立性钙化。

讨论

DAD的发生率为44%,高于血管造影研究中的发生率,这可以通过组织病理学方法来解释,该方法能够诊断出微小的憩室。这些形态学改变至少部分可被视为易发生创伤性主动脉破裂的一个致病因素。

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