Bogdanov M B, Gaĭnetdinov R R, Kudrin V S, Medvedev O S, Val'dman A V
Biull Eksp Biol Med. 1991 May;111(5):505-7.
Using brain microdialysis in awake rats effects of risperidone, ritanserin, buspirone, sulpiride and 5-methoxy-N,N-dimethyltryptamine (MeODMT) on striatal dopamine (DA) release and metabolism were studied. Risperidone, sulpiride and buspirone increased levels of DA, dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA). Ritanserin failed to affect DA release, while increased DOPAC and HVA levels. MeODMT had no effect on striatal DA release and metabolism. Possible interaction between DA and serotonin systems is discussed.
利用清醒大鼠的脑微透析技术，研究了利培酮、利坦色林、丁螺环酮、舒必利和5-甲氧基-N,N-二甲基色胺（MeODMT）对纹状体多巴胺（DA）释放和代谢的影响。利培酮、舒必利和丁螺环酮增加了DA、二羟基苯乙酸（DOPAC）和高香草酸（HVA）的水平。利坦色林未能影响DA释放，但增加了DOPAC和HVA水平。MeODMT对纹状体DA释放和代谢没有影响。文中讨论了DA和5-羟色胺系统之间可能的相互作用。
