Reiff Andreas
Division of Rheumatology, Children's Hospital Los Angeles, CA 90027, USA.
Curr Rheumatol Rep. 2006 Dec;8(6):459-68. doi: 10.1007/s11926-006-0042-2.
Ocular involvement is common in pediatric rheumatologic diseases, supporting the concept that these conditions cannot be understood simply as isolated entities, but rather as multisystem disorders. The reasons for the breach of the eye-brain barrier and the targeting of the usually well-shielded eye during a pan-inflammatory process remains unclear. Pediatric rheumatologists should become familiar with these ocular disorders, because as important members of the treatment team, they manage more serious cases of inflammatory eye disease. A close collaboration between the treating rheumatologist and the ophthalmologist is essential to prevent potentially devastating outcomes. Therapeutic interventions such as topical steroids, systemic immunosuppressants, and biologics must balance the necessity of controlling ocular inflammation and the adverse effects of these treatments on a growing child.
眼部受累在儿童风湿性疾病中很常见，这支持了一种观点，即这些病症不能简单地被视为孤立的实体，而应被视为多系统疾病。在全身性炎症过程中，眼脑屏障被破坏以及通常受到良好保护的眼睛成为攻击目标的原因仍不清楚。儿童风湿病学家应该熟悉这些眼部疾病，因为作为治疗团队的重要成员，他们负责处理更严重的炎症性眼病病例。治疗风湿病的医生和眼科医生之间的密切合作对于预防潜在的灾难性后果至关重要。局部使用类固醇、全身性免疫抑制剂和生物制剂等治疗干预措施必须在控制眼部炎症的必要性与这些治疗方法对成长中儿童的不良影响之间取得平衡。
