Jahan S, Jalali S, Shami S A
Department of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.
Am J Primatol. 2007 Apr;69(4):395-406. doi: 10.1002/ajp.20357.
The present study attempts to examine the role of N-methyl-D, L-aspartate (NMDA) receptors in the central regulation of prolactin (PRL) secretion, which may be involved in ovarian function and its alteration by glutamate in various phases of the menstrual cycle of female rhesus monkeys (Macaca mulatta). The results suggest that the glutaminergic component of the control system, which governs PRL secretion by utilizing NMDA receptors, may have an important role in regulating changes in PRL secretion. The response of PRL during the luteal phase of the cycle was different from that observed in follicular and menstrual phases. Steroids may influence the NMDA-dependent drive to release PRL. N-methyl-D-aspartic acid (NMA) involvement in the regulation of PRL secretion may occur through activation of the PRL-stimulating system depending on the physiological state or steroidal milieu. It is possible, therefore, that the NMA-induced release of PRL-releasing factors (PRF) and PRL are enhanced in the presence of ovarian feedback.
本研究试图探讨N-甲基-D，L-天冬氨酸（NMDA）受体在催乳素（PRL）分泌的中枢调节中的作用，这可能涉及雌性恒河猴（猕猴）月经周期各阶段的卵巢功能及其受谷氨酸的影响。结果表明，利用NMDA受体调控PRL分泌的控制系统中的谷氨酰胺能成分，可能在调节PRL分泌变化中起重要作用。周期黄体期PRL的反应与卵泡期和月经期观察到的不同。类固醇可能影响依赖NMDA释放PRL的驱动力。N-甲基-D-天冬氨酸（NMA）参与PRL分泌的调节可能是通过根据生理状态或甾体环境激活PRL刺激系统来实现的。因此，在存在卵巢反馈的情况下，NMA诱导的PRL释放因子（PRF）和PRL的释放可能会增强。
