Lin Eugene, Hwang Yuchi, Tzeng Chi-Meng
Vita Genomics Inc., Taipei, Taiwan.
Mol Diagn Ther. 2006;10(6):367-70. doi: 10.1007/BF03256213.
Single nucleotide polymorphisms (SNPs) can be used in clinical association studies to determine the contribution of genes to drug efficacy. The goal of this work was to evaluate the feasibility of using SNP information of the Han Chinese in Beijing (CHB) population from the HapMap database for clinical association studies in the Taiwanese (TWN) population.
We compared the HapMap populations with our TWN study population with regard to allele frequencies for common SNPs in two candidate genes for antidepressant treatment response to determine the applicability of the HapMap CHB data for SNP selection in the TWN population.
Our preliminary results suggest that there was no significant difference, in terms of allele and haplotype frequencies, between the CHB population of the HapMap database and the TWN population collected by Vita Genomics Inc. Therefore, it is possible to use the CHB population of the HapMap database for SNP selection in association studies for the TWN population. Using haplotype analysis, we generated a panel of SNPs that may be strongly relevant to antidepressant response in this population.
单核苷酸多态性（SNP）可用于临床关联研究，以确定基因对药物疗效的影响。本研究的目的是评估利用HapMap数据库中北京汉族（CHB）人群的SNP信息，在台湾（TWN）人群中进行临床关联研究的可行性。
我们比较了HapMap人群与我们的TWN研究人群中两个抗抑郁治疗反应候选基因常见SNP的等位基因频率，以确定HapMap CHB数据在TWN人群中进行SNP选择的适用性。
我们的初步结果表明，HapMap数据库中的CHB人群与Vita Genomics Inc.收集的TWN人群在等位基因和单倍型频率方面没有显著差异。因此，有可能将HapMap数据库中的CHB人群用于TWN人群关联研究中的SNP选择。通过单倍型分析，我们生成了一组可能与该人群抗抑郁反应密切相关的SNP。
