Won S J, Lin M T
Department of Microbiology, National Cheng Kung University Medical College, Tainan, Taiwan, Republic of China.
Naunyn Schmiedebergs Arch Pharmacol. 1991 May;343(5):551-7. doi: 10.1007/BF00169561.
Polyadenylic.polyuridylic acid injected intravenously into rabbits produced a rapid-onset, monophasic fever. Pyrogenic tolerance occurred in rabbits following daily injections of polyadenylic.polyuridylic acid. However, direct injection of the agent into the preoptic anterior hypothalamic region of rabbit's brain produced a markedly different fever. After an intrahypothalamic injection of polyadenylic.polyuridylic acid, fever was delayed in onset and persisted for a longer period. At room temperature, the fever was due to both increased metabolism and cutaneous vasoconstriction. In a colder atmosphere the fever was due solely to increased metabolism, whereas in the heat the fever was due to reduction in cutaneous blood flow and respiratory evaporative heat loss. In addition, the fever induced by intravenous polyadenylic.polyuridylic acid injection was reversed by a cyclooxygenase inhibitor, but not by a protein synthesis inhibitor. Polyadenylic.polyuridylic acid was shown to stimulate PGE2 production from rabbit's hypothalamus in vitro. The results reveal that this agent is a prostaglandin-dependent pyrogen.
静脉注射到兔子体内的聚腺苷酸-聚尿苷酸会引发快速发作的单相发热。在每天注射聚腺苷酸-聚尿苷酸后，兔子会产生热原耐受性。然而，将该药剂直接注射到兔子脑的视前区下丘脑前部会产生明显不同的发热。下丘脑内注射聚腺苷酸-聚尿苷酸后，发热的发作延迟且持续时间更长。在室温下，发热是由于代谢增加和皮肤血管收缩。在较冷的环境中，发热仅由于代谢增加，而在炎热环境中，发热是由于皮肤血流量减少和呼吸蒸发散热减少。此外，静脉注射聚腺苷酸-聚尿苷酸引起的发热可被环氧化酶抑制剂逆转，但不能被蛋白质合成抑制剂逆转。体外实验表明，聚腺苷酸-聚尿苷酸能刺激兔子下丘脑产生前列腺素E2。结果表明，该药剂是一种依赖前列腺素的热原。
