Yoshinaga Keiichiro, Tamaki Nagara
Department of Molecular Imaging, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan.
Curr Opin Biotechnol. 2007 Feb;18(1):52-9. doi: 10.1016/j.copbio.2006.11.003. Epub 2006 Dec 8.
The prevalence of coronary artery disease and heart failure is increasing in modern industrialized countries, fueling the search for novel therapies. Because metabolism and function in the heart are inextricably linked, energy substrate metabolism has provided a potential target for novel therapies and the development of technologies to image myocardial metabolism has been crucial in establishing new therapeutic approaches. Nuclear imaging probes have been used to successfully evaluate aerobic fatty acid metabolism, anaerobic glucose metabolism, and oxidative metabolism and can be used for the accurate, sensitive, and physiological evaluation of therapeutic effects. More recently, with the advent of stem-cell technologies, imaging approaches have been employed to track the fate of stem cells and to monitor the success of these treatments. In the future, our ability to image myocardial metabolism is likely to assist the development of other new therapies to improve the function of the failing heart.
在现代工业化国家，冠状动脉疾病和心力衰竭的患病率正在上升，这推动了对新型疗法的探索。由于心脏的代谢与功能紧密相连，能量底物代谢为新型疗法提供了一个潜在靶点，而心肌代谢成像技术的发展对于建立新的治疗方法至关重要。核成像探针已被成功用于评估有氧脂肪酸代谢、无氧葡萄糖代谢和氧化代谢，并且可用于对治疗效果进行准确、灵敏和符合生理的评估。最近，随着干细胞技术的出现，成像方法已被用于追踪干细胞的命运并监测这些治疗的成效。未来，我们对心肌代谢进行成像的能力可能会有助于开发其他新疗法，以改善衰竭心脏的功能。
