Maianskaia N N, Nikolaev Iu A, Shurgaia A M, Gefarova Z M
Lab Delo. 1991(5):15-8.
Examinations of 33 patients with hypertrophic cardiomyopathy have revealed Stages I-II circulation insufficiency in 15. The findings were compared with those in 20 untrained normal subjects and 8 athletes. Lysosomal cationic protein levels were measured in polymorphonuclear leukocytes by the cytochemical method at rest, at the peak of dosed exercise (permanently increasing bicycle spiroergometry) and over the course of the recovery period--in 3, 12, and 24 h after exercise. The neutrophil distribution was also estimated by the staining intensity. Lysosomal cationic protein levels in hypertrophic cardiomyopathy patients with and without circulation insufficiency were changed to a different degree; these characteristics essentially varied in the patients, normal untrained subjects, and athletes. Changed levels of lysosomal cationic proteins appear to reflect the microcirculation disorders and the augmenting hypoxemia in the patients with circulation insufficiency, and thus may be used as a criterion to assess the clinical course of hypertrophic cardiomyopathy.
对33例肥厚型心肌病患者的检查发现，其中15例存在I-II期循环功能不全。将这些结果与20名未经训练的正常受试者和8名运动员的结果进行了比较。通过细胞化学方法在静息状态、定量运动高峰（持续递增自行车运动心肺功能测试）以及恢复期（运动后3、12和24小时）测量多形核白细胞中的溶酶体阳离子蛋白水平。还通过染色强度评估中性粒细胞分布。有和没有循环功能不全的肥厚型心肌病患者的溶酶体阳离子蛋白水平有不同程度的变化；这些特征在患者、未经训练的正常受试者和运动员中基本不同。溶酶体阳离子蛋白水平的变化似乎反映了循环功能不全患者的微循环障碍和低氧血症加重，因此可作为评估肥厚型心肌病临床病程的一个标准。
