Patel Jignesh I
Ophthalmology Department, Royal Perth Hospital, Perth, Australia.
Curr Opin Ophthalmol. 2007 Feb;18(1):9-12. doi: 10.1097/ICU.0b013e3280112a0f.
There is a suggestion of increased risk or progression of age-related macular degeneration after cataract surgery, which is related to the increased exposure of the retina to short-wavelength light.
Cell culture and animal work has described retinal and retinal pigment epithelium phototoxicity on acute light exposure. Clinical studies suggest that the use of short-wavelength-blocking intraocular lenses can help but may also affect visual function and circadian rhythm.
Evidence to date fails to prove conclusively that light alone or cataract surgery can induce or cause the progression of age-related macular degeneration. A randomized clinical study of the use of short-wavelength (blue)-blocking lenses to prove or disprove the ability of these intraocular lenses to help in preventing progression of age-related macular degeneration is needed.
有迹象表明白内障手术后年龄相关性黄斑变性的风险增加或病情进展,这与视网膜暴露于短波长光增加有关。
细胞培养和动物实验表明,视网膜和视网膜色素上皮在急性光暴露下会发生光毒性。临床研究表明,使用能阻挡短波长光的人工晶状体可能有帮助,但也可能影响视觉功能和昼夜节律。
迄今为止的证据未能确凿证明光是导致或引起年龄相关性黄斑变性进展的唯一因素,也未能证明白内障手术会导致该疾病进展。需要进行一项关于使用能阻挡短波长(蓝光)的人工晶状体的随机临床研究,以证实或反驳这些人工晶状体在预防年龄相关性黄斑变性进展方面的作用。