Andreetti C, Anile M, Diso D, Francioni F, Venuta F, De Giacomo T, Di Stasio M, Rendina E A, Coloni G F
Divisione di Chirurgia Toracica, Dipartimento Paride Stefanini, Università degli Studi di Roma La Sapienza, Rome, Italy.
Minerva Chir. 2006 Oct;61(5):367-71.
The esophageal perforations are associated with a high mortality and morbidity when they are not diagnosed and treated quickly. The aim of our study is to analyze the treatment and prognosis of the distal iatrogenic esophageal perforations on the basis of time of onset, concomitant disease and size of perforations.
The retrospective review was performed on 10 patients treated for distal iatrogenic esophageal perforations at our Institution from 1994 to 2003. The cause of perforations was: pneumatic dilation (7 patients) and esophageal endoprosthesis placing (3 patients). Seven patients presented within 24 h (Group A), and 3 patients presented after 24 h (Group B). In Group A, 4 patients underwent primary repair, 2 patients required esophagectomy and 1 patient was treated conservatively. In Group B, 2 patients were treated conservatively and 1 patient required an esophagectomy.
Hospital morbidity was 20% and mortality was 30%. In Group A no patients died. In Group B hospital mortality was 100%. The most common cause of death was multiorgan failure resulting from sepsis.
The prognosis for esophageal perforations is influenced by the time elapsed between diagnosis and treatment. Esophagectomy is indicated for patients with extensive perforation and necrosis of the esophagus when primary repair cannot be carried out. It is indicated also as treatment for the concomitant disease.
食管穿孔若未得到及时诊断和治疗,会导致较高的死亡率和发病率。本研究旨在基于发病时间、伴发疾病及穿孔大小,分析远端医源性食管穿孔的治疗方法及预后情况。
对1994年至2003年在我院接受治疗的10例远端医源性食管穿孔患者进行回顾性研究。穿孔原因包括:气囊扩张术(7例)和食管内支架置入术(3例)。7例患者在24小时内就诊(A组),3例患者在24小时后就诊(B组)。A组中,4例患者接受了一期修复,2例患者需要进行食管切除术,1例患者接受了保守治疗。B组中,2例患者接受了保守治疗,1例患者需要进行食管切除术。
医院发病率为20%,死亡率为30%。A组无患者死亡。B组医院死亡率为100%。最常见的死亡原因是脓毒症导致的多器官功能衰竭。
食管穿孔的预后受诊断和治疗之间间隔时间的影响。当无法进行一期修复时,食管切除术适用于食管广泛穿孔和坏死的患者。它也适用于作为伴发疾病的治疗方法。