Komiyama S, Masuda A, Tomita K, Kuratomi Y, Zingu K
Dept. of Otorhinolaryngology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Gan To Kagaku Ryoho. 1991 Sep;18(12):2090-4.
Clinical results of cases of hypopharyngeal carcinoma treated from 1966 to 1990 at Kyushu University Hospital were investigated. In 1966-1972, all cases were treated with only radical operation. We used FAR therapy since 1972, and preoperative chemotherapy (CDDP and Peplomycin) in addition to FAR therapy since 1984. The crude five-year survival rate of the operative therapy-group (25 cases in 1966-1972) was 24%, and that of the FAR therapy-group with or without operation (47 cases in 1972-1980) was 38%. Although it was cumulative survival rate by Kaplan-Meier's method, the five-year survival rate of the group (16 cases in 1984-1990) treated with a combination of FAR therapy, preoperative-chemotherapy, and operation was 76%. The improvement in the survival rate and the role of preoperative treatment (FAR therapy and chemotherapy) are discussed.
对1966年至1990年在九州大学医院接受治疗的下咽癌病例的临床结果进行了调查。1966年至1972年，所有病例仅接受根治性手术治疗。自1972年起我们采用FAR疗法，自1984年起除FAR疗法外还采用术前化疗（顺铂和培洛霉素）。手术治疗组（1966年至1972年的25例）的粗略五年生存率为24%，采用FAR疗法且有或无手术治疗的组（1972年至1980年的47例）的五年生存率为38%。尽管这是采用Kaplan-Meier法计算的累积生存率，但采用FAR疗法、术前化疗和手术联合治疗的组（1984年至1990年的16例）的五年生存率为76%。本文讨论了生存率的提高以及术前治疗（FAR疗法和化疗）的作用。
