Haliloglu Ahmet, Baltaci Sumer, Yaman Onder
University of Ankara, Faculty of Medicine, Department of Urology, Ankara, Turkey.
J Urol. 2007 Jan;177(1):128-30. doi: 10.1016/j.juro.2006.08.113.
We determined penile length alterations in men treated with androgen suppression plus radiation therapy for local or locally advanced prostate cancer.
From November 2000 to November 2005, 47 patients were enrolled in this prospective study. After clinical staging all patients received hormonal therapy (luteinizing hormone releasing agonist, leuprolide acetate or goserelin every 3 months for a total of 3 injections) and at month 7 of hormonal therapy radiation therapy was begun (total 70 Gy) for 7 weeks. Stretched penile length measurements were performed before starting androgen suppression therapy and every 3 months thereafter with a paper ruler.
With the initiation of therapy a gradual decrease in stretched penile length was observed. Penile shortening was statistically significant at a mean followup of 18 months (mean 14.2 to 8.6 cm, p <0.001).
Our findings support observations of decreased penile length after neoadjuvant hormonal therapy plus external beam radiation therapy for local or locally advanced prostate cancer. Patients should be counseled before therapy that penile shortening may occur.
我们确定了接受雄激素抑制联合放射治疗的局部或局部晚期前列腺癌男性患者的阴茎长度变化。
2000年11月至2005年11月，47例患者纳入这项前瞻性研究。临床分期后，所有患者接受激素治疗（促黄体生成素释放激动剂，醋酸亮丙瑞林或戈舍瑞林，每3个月注射一次，共注射3次），在激素治疗第7个月开始放射治疗（总量70Gy），为期7周。在开始雄激素抑制治疗前及之后每3个月用纸质直尺测量阴茎拉伸长度。
随着治疗开始，观察到阴茎拉伸长度逐渐下降。在平均随访18个月时阴茎缩短具有统计学意义（平均从14.2cm降至8.6cm，p<0.001）。
我们的研究结果支持了对于局部或局部晚期前列腺癌新辅助激素治疗加外照射放疗后阴茎长度下降的观察结果。应在治疗前告知患者可能会出现阴茎缩短。
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