Kadono Yoshifumi, Nohara Takahiro, Kawaguchi Shohei, Iwamoto Hiroaki, Yaegashi Hiroshi, Shigehara Kazuyoshi, Izumi Kouji, Mizokami Atsushi
Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, 13-1 Takara-machi, Kanazawa 920-8640, Ishikawa, Japan.
Cancers (Basel). 2022 Jun 21;14(13):3050. doi: 10.3390/cancers14133050.
During radical prostatectomy, the prostate is removed along with the seminal vesicles, and the urinary tract is reconstructed by dropping the bladder onto the pelvic floor and suturing the bladder and urethra together. This process causes damage to the pelvic floor and postoperative complications due to the anatomical changes in the pelvic floor caused by the vesicourethral anastomosis. Urinary incontinence and erectile dysfunction are major complications that impair patients' quality of life after radical prostatectomy. In addition, the shortening of the penis and the increased prevalence of inguinal hernia have been reported. Since these postoperative complications subsequently affect patients' quality of life, their reduction is a matter of great interest, and procedural innovations such as nerve-sparing techniques, Retzius space preservation, and inguinal hernia prophylaxis have been developed. It is clear that nerve sparing is useful for preserving the erectile function, and nerve sparing, urethral length preservation, and Retzius sparing are useful for urinary continence. The evaluation of pre- and postoperative imaging to observe changes in pelvic anatomy is also beginning to clarify why these techniques are useful. Changes in pelvic anatomy after radical prostatectomy are inevitable and, therefore, postoperative complications cannot be completely eliminated; however, preserving as much of the tissue and structure around the prostate as possible, to the extent that prostate cancer control is not compromised, may help reduce the prevalence of postoperative complications.
在根治性前列腺切除术中,前列腺连同精囊一起被切除,通过将膀胱下拉至盆底并将膀胱与尿道缝合在一起重建尿路。由于膀胱尿道吻合术导致盆底解剖结构改变,这一过程会对盆底造成损伤并引发术后并发症。尿失禁和勃起功能障碍是根治性前列腺切除术后影响患者生活质量的主要并发症。此外,还报道了阴茎缩短和腹股沟疝患病率增加的情况。由于这些术后并发症随后会影响患者的生活质量,减少并发症备受关注,因此已经开发了诸如保留神经技术、保留耻骨后间隙和预防腹股沟疝等手术创新方法。显然,保留神经有助于保留勃起功能,而保留神经、保留尿道长度和保留耻骨后间隙对尿失禁有帮助。术前和术后影像学评估以观察盆腔解剖结构的变化,也开始阐明这些技术为何有用。根治性前列腺切除术后盆腔解剖结构的改变是不可避免的,因此术后并发症无法完全消除;然而,在不影响前列腺癌控制的前提下,尽可能多地保留前列腺周围的组织和结构,可能有助于降低术后并发症的发生率。