Galkin A P, Mironova L N, Zhuravleva G A, Inge-Vechtomov S G
Genetika. 2006 Nov;42(11):1558-70.
Prion proteins are infective amyloids and cause several neurodegenerative diseases in humans and animals. In yeasts, prions are expressed as cytoplasmic heritable determinants of a protein nature. Yeast prion [PSI], which results from a conformational rearrangement and oligomerization of translation termination factor eRF3, is used as an example to consider the structural--functional relationships in a potentially prion molecule, specifics of its evolution, and interactions with other prions, which form so-called prion networks. In addition, the review considers the results of modeling mammalian prion diseases and other amyloidoses in yeast cells. A hypothesis of proteomic networks is proposed by analogy with prion networks, involving interactions of different amyloids in mammals.
朊病毒蛋白是感染性淀粉样蛋白，可在人类和动物中引发多种神经退行性疾病。在酵母中，朊病毒以蛋白质性质的细胞质可遗传决定因素的形式表达。酵母朊病毒[PSI]由翻译终止因子eRF3的构象重排和寡聚化产生，以此为例来探讨潜在朊病毒分子中的结构-功能关系、其进化特点以及与其他朊病毒的相互作用，这些相互作用形成了所谓的朊病毒网络。此外，该综述还探讨了在酵母细胞中模拟哺乳动物朊病毒疾病和其他淀粉样变性的结果。通过类比朊病毒网络提出了蛋白质组网络的假说，该假说涉及哺乳动物中不同淀粉样蛋白的相互作用。
