A 型 DNA/2'-O-甲基核糖核酸杂交体中的空穴转移速率

Hole transfer rates in A-form DNA/2'-OMeRNA hybrid.

作者信息

Kawai Kiyohiko, Osakada Yasuko, Sugimoto Akira, Fujitsuka Mamoru, Majima Tetsuro

机构信息

The Institute of Scientific and Industrial Research (SANKEN), Osaka University, Mihogaoka 8-1, Ibaraki, Osaka 567-0047, Japan.

出版信息

Chemistry. 2007;13(8):2386-91. doi: 10.1002/chem.200601210.

DOI:10.1002/chem.200601210

PMID:17163564

Abstract

The hole transfer rates in the DNA/DNA B-form duplex and DNA/2'-OMeRNA A-form duplex were measured which occurred in the time range of approximately 100 micros. The hole transfer rates in the A-form duplexes were slower and more strongly dependent on the temperature compared to those in the B-form duplexes, suggesting that the A-form is more rigid than the B-form duplex in this time scale.

摘要

测量了DNA/DNA B型双链体和DNA/2'-O-甲基RNA A型双链体中的空穴转移速率，这些过程发生在大约100微秒的时间范围内。与B型双链体相比，A型双链体中的空穴转移速率较慢，且对温度的依赖性更强，这表明在这个时间尺度上，A型双链体比B型双链体更刚性。