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通过与病毒体结合增强合成碳水化合物的免疫原性:一种利什曼病候选疫苗。

Enhancement of the immunogenicity of synthetic carbohydrates by conjugation to virosomes: a leishmaniasis vaccine candidate.

作者信息

Liu Xinyu, Siegrist Sibylle, Amacker Mario, Zurbriggen Rinaldo, Pluschke Gerd, Seeberger Peter H

机构信息

Laboratorium für Organische Chemie, ETH Zürich, Wolfgang-Pauli Strasse 10, 8093 Zürich, Switzerland.

出版信息

ACS Chem Biol. 2006 Apr 25;1(3):161-4. doi: 10.1021/cb600086b.

Abstract

Novel virosomal formulations of a synthetic oligosaccharide were prepared and evaluated as vaccine candidates against leishmaniasis. A lipophosphoglycan-related synthetic tetrasaccharide antigen was conjugated to a phospholipid and to the influenza virus coat protein hemagglutinin. These glycan conjugates were embedded into the lipid membrane of reconstituted influenza virus virosomes. The virosomal formulations elicited both IgM and IgG anti-glycan antibodies in mice, indicating an antibody isotype class switch to IgG. The antisera cross-reacted in vitro with the corresponding natural carbohydrate antigens expressed by leishmania cells. These findings support the concept of using virosomes as universal antigen delivery platform for synthetic carbohydrate vaccines.

摘要

制备了一种合成寡糖的新型病毒体配方,并将其作为抗利什曼病的候选疫苗进行评估。一种与脂磷壁酸相关的合成四糖抗原与磷脂和流感病毒包膜蛋白血凝素偶联。这些聚糖偶联物被嵌入重组流感病毒病毒体的脂质膜中。病毒体配方在小鼠体内引发了IgM和IgG抗聚糖抗体,表明抗体亚型转换为IgG。抗血清在体外与利什曼原虫细胞表达的相应天然碳水化合物抗原发生交叉反应。这些发现支持了将病毒体用作合成碳水化合物疫苗通用抗原递送平台的概念。

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