Snøve Ola, Rossi John J
Division of Molecular Biology, Graduate School of Biological Sciences, Beckman Research Institute of the City of Hope, 1450 East Duarte Road, Duarte, California 91010, USA.
ACS Chem Biol. 2006 Jun 20;1(5):274-6. doi: 10.1021/cb6002256.
RNAi's specificity has been questioned for some time. Three recent papers show that off-target effects should be considered normal, but one paper also provides insight on how chemical modifications of siRNAs may overcome the problem.
一段时间以来，RNA干扰的特异性一直受到质疑。最近的三篇论文表明，脱靶效应应被视为正常现象，但有一篇论文也提供了关于小干扰RNA的化学修饰如何可能克服这一问题的见解。
