热休克蛋白90抑制剂的肿瘤选择性：其原因仍不清楚。
Tumor selectivity of Hsp90 inhibitors: the explanation remains elusive.
作者信息
Chiosis Gabriela, Neckers Len
机构信息
Department of Medicine and Program in Molecular Pharmacology and Chemistry, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA.
出版信息
ACS Chem Biol. 2006 Jun 20;1(5):279-84. doi: 10.1021/cb600224w.
PMID:17163756
Abstract
Two recent papers attempt to solve both the tumor selectivity and the in vivo tumor accumulation profiles seen with some Hsp90 inhibitors. They spotlight the higher affinity of ansamycins' hydroquinone over the quinone form for Hsp90 and further discuss its possible contribution to ansamycins' tumor selectivity.
摘要
最近的两篇论文试图解决一些Hsp90抑制剂所表现出的肿瘤选择性和体内肿瘤蓄积情况。它们突出了安莎霉素的对苯二酚形式相对于醌形式对Hsp90具有更高的亲和力，并进一步讨论了其对安莎霉素肿瘤选择性的可能贡献。
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