Solit David B, Chiosis Gabriela
Department of Medicine and the Human Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, United States.
Drug Discov Today. 2008 Jan;13(1-2):38-43. doi: 10.1016/j.drudis.2007.10.007. Epub 2007 Nov 26.
Heat shock protein 90 has emerged as an important target in several diseases. The present review will discuss our understanding of the role played by Hsp90 in regulating and maintaining the transformed phenotype in cancers and neurodegenerative diseases, as well as recent findings on its roles in fungal and viral infections. It will also update the reader on the preclinical development and clinical translation of Hsp90 inhibitors.
热休克蛋白90已成为多种疾病的重要靶点。本综述将讨论我们对热休克蛋白90在调节和维持癌症及神经退行性疾病的转化表型中所起作用的理解，以及其在真菌和病毒感染中作用的最新研究结果。它还将向读者介绍热休克蛋白90抑制剂的临床前开发和临床转化情况。
