静脉血栓栓塞症患者血小板糖蛋白Ia 807C/T和873G/A基因多态性

Platelet glycoprotein Ia 807C/T and 873G/A polymorphisms in patients with venous thromboembolism.

作者信息

Okumus Gulfer, Kiyan Esen, Arseven Orhan, Tabak Levent, Bayrak Evrim Komurcu, Unaltuna Nihan Erginel, Issever Halim

机构信息

Istanbul Medical Faculty, Department of Pulmonary Diseases, Istanbul University, Turkey.

出版信息

Clin Appl Thromb Hemost. 2007 Jan;13(1):101-3. doi: 10.1177/1076029606296422.

DOI:10.1177/1076029606296422

PMID:17164499

Abstract

Two silent polymorphisms (807C/T and 873G/A) within glycoprotein Ia (GPIa) gene have been implicated in increased risk of developing thrombosis and myocardial infarction in affected individuals. The aim of this study was to investigate the GPIa gene polymorphism in patients with venous thromboembolism (VTE). A multiplexed allele specific-polymerase chain reaction (AS-PCR)-based method was used to determine the GPIa 807T/873A allele frequency in 77 patients with VTE and 106 healthy controls. The allelic frequency for 807T/873A was 33% in the patient group and 38% in the control group. The allelic frequency for 807C/873G was 66% in the patient group and 62% in the control group. The genotypic frequencies were 8% for 807TT/873AA, 42% for 807CC/GG, and 50% for 807CT/GA in the patient group. In the control group, the frequencies were 12% for 807TT/873AA, 35% for 807CC/873GG, and 52% for 807CT/873GA. As a result, the glycoprotein Ia 807C/T and 873G/A dimorphisms were not shown as risk factors for VTE.

摘要

糖蛋白Ia（GPIa）基因内的两种沉默多态性（807C/T和873G/A）与受影响个体发生血栓形成和心肌梗死的风险增加有关。本研究的目的是调查静脉血栓栓塞症（VTE）患者的GPIa基因多态性。采用基于多重等位基因特异性聚合酶链反应（AS-PCR）的方法，测定77例VTE患者和106例健康对照者中GPIa 807T/873A等位基因频率。患者组中807T/873A的等位基因频率为33%，对照组为38%。患者组中807C/873G的等位基因频率为66%，对照组为62%。患者组中807TT/873AA的基因型频率为8%，807CC/GG为42%，807CT/GA为50%。对照组中，807TT/873AA的频率为12%，807CC/873GG为35%，807CT/873GA为52%。结果表明，糖蛋白Ia 807C/T和873G/A二态性并非VTE的危险因素。