de Oliveira Mônica H C F, André Charles, Spector Nelson, Luiz Ronir Raggio, de Castro Souza Gizele, Gadelha Telma
Hematology Service, Department of Internal Medicine, Hospital Universitário Clementino Fraga Filho, Federal University of Rio de Janeiro, Brazil.
Blood Coagul Fibrinolysis. 2007 Oct;18(7):599-602. doi: 10.1097/MBC.0b013e3282010ad0.
Platelet membrane glycoprotein receptors mediate key reactions in arterial thrombosis. The relationship between glycoprotein Ia polymorphisms and the risk of ischemic stroke, however, remains controversial. A matched case-control study was conducted to evaluate this question in young patients. Seventy patients with ischemic stroke of undetermined etiology, with ages ranging from 15 to 50 years, and 70 healthy control individuals, matched by age, gender and ethnicity, were tested for the 807C/T genotypes. Patients were excluded if they had systemic diseases known to predispose to thrombosis or any defined etiology of ischemic stroke. The frequencies of the 807T glycoprotein Ia variant and of conventional risk factors for arterial thrombosis (hypertension, smoking, diabetes mellitus, use of oral contraceptives, levels of serum cholesterol and body mass index) were compared in stroke patients and control individuals. The 807T allele was found in 61% of patients and 53% of control individuals (matched-pair odds ratio, 1.38; 95% confidence interval, 0.69-2.74; P = 0.42). Arterial hypertension and smoking were more frequent in patients than control individuals (matched-pair odds ratio, 2.83; 95% confidence interval, 1.05-8.02; P = 0.04; and odds ratio, 3.20; 95% confidence interval, 1.10-9.97, P = 0.03, respectively). In conclusion, our results do not support an independent association between the 807C/T polymorphism and stroke of undetermined etiology. The interplay of this polymorphism with arterial hypertension in the causation of ischemic stroke requires further evaluation.
血小板膜糖蛋白受体介导动脉血栓形成中的关键反应。然而，糖蛋白Ia多态性与缺血性中风风险之间的关系仍存在争议。我们进行了一项匹配病例对照研究，以评估年轻患者中的这一问题。对70例病因不明的缺血性中风患者（年龄在15至50岁之间）和70名年龄、性别和种族相匹配的健康对照个体进行了807C/T基因型检测。如果患者患有已知易患血栓形成的全身性疾病或任何明确病因的缺血性中风，则将其排除。比较了中风患者和对照个体中807T糖蛋白Ia变体的频率以及动脉血栓形成的传统危险因素（高血压、吸烟、糖尿病、口服避孕药使用情况、血清胆固醇水平和体重指数）。在61%的患者和53%的对照个体中发现了807T等位基因（配对优势比为1.38；95%置信区间为0.69 - 2.74；P = 0.42）。患者中动脉高血压和吸烟的发生率高于对照个体（配对优势比分别为2.83；95%置信区间为1.05 - 8.02；P = 0.04；以及优势比为3.20；95%置信区间为1.10 - 9.97，P = 0.03）。总之，我们的结果不支持807C/T多态性与病因不明的中风之间存在独立关联。这种多态性与动脉高血压在缺血性中风病因中的相互作用需要进一步评估。
