一种用于选择性铜传感的智能磁共振造影剂。

A smart magnetic resonance contrast agent for selective copper sensing.

作者信息

Que Emily L, Chang Christopher J

机构信息

Department of Chemistry, University of California, Berkeley, California 94720, USA.

出版信息

J Am Chem Soc. 2006 Dec 20;128(50):15942-3. doi: 10.1021/ja065264l.

DOI:10.1021/ja065264l

PMID:17165700

Abstract

We describe the synthesis and properties of Copper-Gad-1 (CG1), a new type of smart magnetic resonance (MR) sensor for selective detection of copper. CG1 is composed of a gadolinium contrast agent core tethered to copper-selective recognition motif. Cu2+-induced modulation of inner-sphere water access to the Gd3+ center provides a sensing mechanism for reporting Cu2+ levels by reading out changes in longitudinal proton relaxivity values. CG1 features good selectivity for Cu2+ over abundant biological cations and a 41% increase in relaxivity upon Cu2+ binding and is capable of detecting micromolar changes in Cu2+ concentrations in aqueous media.

摘要

我们描述了新型智能磁共振（MR）传感器铜-钆-1（CG1）的合成及其特性，该传感器用于选择性检测铜。CG1由连接到铜选择性识别基序的钆造影剂核心组成。Cu2+诱导的内球层水进入Gd3+中心的调制提供了一种传感机制，通过读出纵向质子弛豫率值的变化来报告Cu2+水平。CG1对Cu2+具有优于丰富生物阳离子的良好选择性，并且在与Cu2+结合后弛豫率增加41%，能够检测水性介质中Cu2+浓度的微摩尔变化。