Yue Ping, Nagendraraj Thavasilingam, Wang Gaoji, Jin Ziyi, Angelovski Goran
Laboratory of Molecular and Cellular Neuroimaging, International Center for Primate Brain Research (ICPBR), Center for Excellence in Brain Science and Intelligence Technology (CEBSIT), Chinese Academy of Sciences (CAS) Shanghai 201602 PR China
School of Chemistry and Chemical Engineering, Jiangsu University Zhenjiang 212013 PR China.
Chem Sci. 2024 Nov 27;15(48):20122-20154. doi: 10.1039/d4sc04849k. eCollection 2024 Dec 11.
Magnetic resonance imaging (MRI) has become an indispensable tool in biomedical research and clinical radiology today. It enables the tracking of physiological changes noninvasively and allows imaging of specific biological processes at the molecular or cellular level. To this end, bioresponsive MRI probes can greatly contribute to improving the specificity of MRI, as well as significantly expanding the scope of its application. A large number of these sensor probes has been reported in the past two decades. Importantly, their development was done hand in hand with the ongoing advances in MRI, including emerging methodologies such as chemical exchange saturation transfer (CEST) or hyperpolarised MRI. Consequently, several approaches on successfully using these probes in functional imaging studies have been reported recently, giving new momentum to the field of molecular imaging, also the chemistry of MRI probes. This Perspective summarizes the major strategies in the development of bioresponsive MRI probes, highlights the major research directions within an individual group of probes ( - and -weighted, CEST, fluorinated, hyperpolarised) and discusses the practical aspects that should be considered in designing the MRI sensors, up to their intended application .
磁共振成像（MRI）如今已成为生物医学研究和临床放射学中不可或缺的工具。它能够以非侵入性方式追踪生理变化，并能在分子或细胞水平对特定生物过程进行成像。为此，生物响应性MRI探针可极大地有助于提高MRI的特异性，并显著扩展其应用范围。在过去二十年中已报道了大量此类传感探针。重要的是，它们的发展与MRI的不断进步同步进行，包括诸如化学交换饱和转移（CEST）或超极化MRI等新兴方法。因此，最近已有多篇关于在功能成像研究中成功使用这些探针的方法的报道，为分子成像领域以及MRI探针化学带来了新的动力。本综述总结了生物响应性MRI探针开发中的主要策略，突出了各探针组（T1加权、T2加权、CEST、氟化、超极化）内的主要研究方向，并讨论了在设计MRI传感器直至其预期应用时应考虑的实际问题。
