烯丙基钯极性反转在高烯丙基胺的三组分偶联合成中的应用
Allylpalladium umpolung in the three-component coupling synthesis of homoallylic amines.
作者信息
Hopkins Chad D, Malinakova Helena C
机构信息
Department of Chemistry, University of Kansas, 1251 Wescoe Hall Drive, Lawrence, Kansas 66045-7582, USA.
出版信息
Org Lett. 2006 Dec 21;8(26):5971-4. doi: 10.1021/ol0624528.
PMID:17165907
Abstract
[Structure: see text] Homoallylic amines and alpha-amino esters were prepared via a Pd(II)-catalyzed coupling of boronic acids and 1,2-nonadiene with ethyl iminoacetate or aliphatic, aromatic, and heteroaromatic imines. The allylpalladium umpolung was induced by a Pd(OAc)2 catalyst with commercial phosphine ligands.
摘要
[结构：见正文] 通过钯（II）催化硼酸与1,2-壬二烯与亚氨基乙酸乙酯或脂肪族、芳香族和杂芳香族亚胺的偶联反应制备了高烯丙基胺和α-氨基酯。烯丙基钯的极性翻转由醋酸钯催化剂与市售膦配体引发。
Zotero 插件