Identification of a Moraxella catarrhalis gene that confers adherence to various human epithelial cell lines in vitro.
作者信息
Lipski Serena L, Holm Melissa M, Lafontaine Eric R
机构信息
Department of Medical Microbiology and Immunology, Medical University of Ohio, Toledo, OH 43614, USA.
出版信息
FEMS Microbiol Lett. 2007 Feb;267(2):207-13. doi: 10.1111/j.1574-6968.2006.00549.x. Epub 2006 Dec 8.
Abstract
Moraxella catarrhalis is a pathogen of the human airways. We found that expression of the M. catarrhalis gene mcmA by Escherichia coli increases adherence to epithelial cells 100-fold. Furthermore, we discovered that disrupting mcmA decreases M. catarrhalis adherence to laryngeal and lung cells, which are relevant to pathogenesis by the bacterium.
摘要
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